ParkinsonCanadaV1, Main, Exploration, bibRecord, 003091

Dopamine release in human ventral striatum and expectation of reward

Identifieur interne : 003091 ( Main/Exploration ); précédent : 003090; suivant : 003092

Dopamine release in human ventral striatum and expectation of reward

Auteurs : Raul De La Fuente-Fernandez [Canada] ; Anthony G. Phillips [Canada] ; Mariangela Zamburlini [Canada] ; Vesna Sossi [Canada] ; Donald B. Calne [Canada] ; Thomas J. Ruth [Canada] ; A. Jon Stoessl [Canada]

Source :

Behavioural brain research [ 0166-4328 ] ; 2002.

RBID : Pascal:03-0028149

Descripteurs français

Pascal (Inist)
- Récepteur dopaminergique D2, Récepteur dopaminergique D3, Raclopride, Corps strié, Noyau accumbens, Tomographie, Parkinson maladie, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antiparkinson Agents (pharmacology), Apomorphine (pharmacology), Corpus striatum, D2 Dopamine receptor, D3 Dopamine receptor, Dopamine (metabolism), Dopamine Antagonists, Human, Humans, Neostriatum (diagnostic imaging), Neostriatum (metabolism), Nucleus Accumbens (diagnostic imaging), Nucleus Accumbens (metabolism), Nucleus accumbens, Parkinson Disease (diagnostic imaging), Parkinson Disease (metabolism), Parkinson Disease (psychology), Parkinson disease, Raclopride, Reward, Tomography, Tomography, Emission-Computed.
MESH :
- chemical , metabolism : Dopamine.
- chemical , pharmacology : Antiparkinson Agents, Apomorphine.
- chemical : Dopamine Antagonists, Raclopride.
- diagnostic imaging : Neostriatum, Nucleus Accumbens, Parkinson Disease.
- metabolism : Neostriatum, Nucleus Accumbens, Parkinson Disease.
- psychology : Parkinson Disease.
- Humans, Reward, Tomography, Emission-Computed.

Abstract

Using the ability of [¹¹C]raclopride to compete with dopamine for D₂/D₃ receptors, we investigated by positron emission tomography the effect of placebo (saline) injection on dopamine release in the ventral striatum of patients with Parkinson's disease. We found evidence for placebo-induced dopamine release of similar magnitude to that reported in healthy volunteers after amphetamine administration. However, in contrast to the dorsal striatum, there were no differences in [¹¹C]raclopride binding potential changes between patients who experienced the reward (those who reported placebo-induced clinical benefit) and those who did not. We conclude that the release of dopamine in the ventral striatum (nucleus accumbens) is related to the expectation of reward and not to the reward itself. These observations have potential implications for the treatment of drug addiction.

Affiliations:

Canada

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (pharmacology)</term>
<term>Apomorphine (pharmacology)</term>
<term>Corpus striatum</term>
<term>D2 Dopamine receptor</term>
<term>D3 Dopamine receptor</term>
<term>Dopamine (metabolism)</term>
<term>Dopamine Antagonists</term>
<term>Human</term>
<term>Humans</term>
<term>Neostriatum (diagnostic imaging)</term>
<term>Neostriatum (metabolism)</term>
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<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson disease</term>
<term>Raclopride</term>
<term>Reward</term>
<term>Tomography</term>
<term>Tomography, Emission-Computed</term>
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<front><div type="abstract" xml:lang="en">Using the ability of [<sup>11</sup>
C]raclopride to compete with dopamine for D<sub>2</sub>
/D<sub>3</sub>
 receptors, we investigated by positron emission tomography the effect of placebo (saline) injection on dopamine release in the ventral striatum of patients with Parkinson's disease. We found evidence for placebo-induced dopamine release of similar magnitude to that reported in healthy volunteers after amphetamine administration. However, in contrast to the dorsal striatum, there were no differences in [<sup>11</sup>
C]raclopride binding potential changes between patients who experienced the reward (those who reported placebo-induced clinical benefit) and those who did not. We conclude that the release of dopamine in the ventral striatum (nucleus accumbens) is related to the expectation of reward and not to the reward itself. These observations have potential implications for the treatment of drug addiction.</div>
</front>
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<name sortKey="Ruth, Thomas J" sort="Ruth, Thomas J" uniqKey="Ruth T" first="Thomas J." last="Ruth">Thomas J. Ruth</name>
<name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name>
<name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name>
<name sortKey="Zamburlini, Mariangela" sort="Zamburlini, Mariangela" uniqKey="Zamburlini M" first="Mariangela" last="Zamburlini">Mariangela Zamburlini</name>
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</record>

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La maladie de Parkinson au Canada (serveur d'exploration)

Dopamine release in human ventral striatum and expectation of reward

Dopamine release in human ventral striatum and expectation of reward

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.